Article: What to Expect After 90 Days of Taking Livital

Share

Aug 30, 2025

What to Expect After 90 Days of Taking Livital

Livital is marketed as a liver‑detox and revitalisation supplement. It combines several Ayurvedic herbs, including Kalmegh (Andrographis paniculata), Guduchi (Tinospora cordifolia), Bhringaraj (Eclipta alba), Punarnava (Boerhavia diffusa), Kasani (Cichorium intybus) and other botanicals such as tamalaki, katuka, vidanga and rohitaka.

According to the product information from Zandu Care, the tablets are intended to support liver and kidney health, improve metabolism and digestion and provide a detox effect when taken twice daily. Visible results are advertised in about two months.

Scientific Evidence on Polyherbal Liver Formulations

Study Details	Findings
Type of Study	Phase-IV, open-label clinical trial
Formula Tested	Liv.52 DS (related polyherbal formula, not Livital)
Sample Size	962 patients with mild-to-moderate liver disorders
Dosage	Two tablets, twice daily, for 12 weeks (≈90 days)
Outcome Measures	Improvements in liver enzyme and biomarker levels
Results	- 75% showed improved AST (aspartate aminotransferase) - 81% improved ALT (alanine aminotransferase) - 70% improved serum bilirubin - 79% improved ALP (alkaline phosphatase)
Statistical Significance	All improvements were significant (P < 0.0001)

Note: This study tested Liv.52 DS, not Livital. However, it indicates that polyherbal liver formulations may improve liver enzyme profiles over a 90-day period.

Below is a week‑by‑week guide synthesising evidence from this research, clinical trials on individual herbs and the product’s claims.

It is intended to provide a general idea of how your body might respond to Livital. Remember that individual responses vary, and you should consult a healthcare professional before starting any supplement.

Weeks 1–2: Gentle Detox and Digestive Support

Improved appetite and digestion: Punarnava and Bhringaraj are traditionally used to support digestion and reduce bloating. Bhringaraj contains phytochemicals that show hepatoprotective effects in animal studies, but human evidence is limited.

Subtle energy lift: As the herbs start supporting digestion, some users report feeling slightly lighter after meals. Guduchi is thought to help modulate immunity and metabolism, but LiverTox notes that none of its claimed benefits have been proven in human studies.

No major liver enzyme changes yet: In the Liv.52 DS study, most biochemical improvements were observed after several weeks of continuous use.

Weeks 3-4: Metabolic and Appetite Benefits

Better metabolism and less bloating: Kalmegh (Andrographis paniculata) contains andrographolide, which has anti‑inflammatory and antioxidant properties.

However, a Thai cross‑sectional study found that people taking Andrographis for gastrointestinal problems had slightly higher ALT and AST levels compared with non‑users. This suggests that high doses may strain the liver, so staying within recommended dosages is essential.

Support for kidney function: Punarnava and Kalmegh are considered diuretics and may help flush excess water from the body. Evidence is anecdotal, mainly or derived from animal studies.

Mild improvements in fatigue: Participants in the Liv.52 DS trial reported reductions in fatigue and anorexia symptoms by week 12, suggesting that energy levels may start improving by the end of this phase.

Weeks 5–6: Visible Changes in Liver Function Markers

Liver enzyme improvements begin: In the Liv.52 DS study, improvements in ALT, AST, bilirubin and ALP became significant around this time.

A separate double‑blind trial on burn patients found that chicory seed syrup (Cichorium intybus) decreased liver enzyme levels over 15 days. However, the difference from silymarin (milk thistle) was not significant.

Better digestion and appetite: Zandu notes that Livital improves appetite and digestion. Anecdotal reports often mention fewer episodes of nausea and a more regular appetite during this period.

Stay mindful of dosage: Andrographis consumption is associated with an increased risk of ALT elevation (adjusted odds ratio 1.62) so avoid exceeding recommended doses and consult a doctor if you have underlying liver issues.

Weeks 7–8: Metabolic Balance and Energy Gains

Enhanced metabolism and weight management: As the liver becomes more efficient at processing fats and toxins, some users may notice gradual weight stabilisation. Chicory (Kasani) contains inulin, a prebiotic fibre that can support gut microbiota and may improve blood sugar and cholesterol profiles.

Reduced abdominal discomfort: The diuretic and detoxifying herbs may help reduce water retention and discomfort around the abdomen. Again, data from human studies are limited; most evidence comes from preclinical research.

Improved mood and daily vitality: With digestion and liver function improving, you might experience better sleep and morning energy. However, Guduchi’s benefits on immune function remain unproven in humans.

Weeks 9–10: Liver Health and Wellbeing

Noticeable improvement in liver enzymes: Based on the Liv.52 DS trial, by around week 9, many participants had normalised ALT and AST levels. Serum bilirubin and ALP levels also improved in ~70–79 % of participants.

Better skin and hair: Bhringaraj and tamalaki are traditionally used for hair and skin health. While there is limited clinical research, users often report a healthier complexion as toxins are cleared more efficiently.

Caution with Guduchi: LiverTox reports more than 50 cases of acute liver injury linked to Tinospora cordifolia; the cases range from mild enzyme elevations to severe hepatitis. If you notice jaundice (yellowing of skin or eyes) or dark urine, stop the supplement and seek medical advice.

Weeks 11–12: Peak Benefits and Overall Wellness

Highest improvement in quality of life: The Liv.52 DS study measured quality‑of‑life scores and found significant improvements across all domains at 12 weeks. Fatigue, anorexia, and jaundice symptoms decreased markedly.

Stable digestion and metabolism: By this stage, your digestive system may feel more regular, and energy levels more consistent. Chicory’s prebiotic fibre continues to support gut health.

Monitoring and maintenance: Continue regular liver function tests if you have pre‑existing liver conditions. Stop the supplement if any unusual symptoms occur.

Key Signs That Livital May be Working

Indicator	Evidence/notes
Reduced fatigue and improved appetite	In the Liv.52 DS study, almost half of patients experienced relief from fatigue and appetite loss by week 12.
Improved liver enzymes	75 % of patients showed improved AST, 81 % improved ALT, 70 % reduced bilirubin and 79 % improved ALP by week 12.
Better digestion and metabolism	Product information notes improved digestion and appetite; chicory seed trials showed decreased liver enzyme levels over 15 days.
Stable weight and reduced bloating	Punarnava and Kalmegh have diuretic and digestive properties; anecdotal reports suggest less water retention and better metabolism, though clinical evidence is limited.
No significant side effects	The Liv.52 DS trial reported few adverse events (2.6 % abdominal pain and 1.7 % headache) and no serious safety signals.

The Outcome

Livital is a polyherbal supplement designed to support liver health, digestion and metabolism. The strongest evidence for similar formulas comes from a 12‑week open‑label study of Liv.52 DS, where around 75–81 % of participants experienced improvements in liver enzyme levels and clinical symptoms.

Individual herbs such as chicory show promise in reducing liver enzymes, while others like Andrographis may elevate ALT if taken at high doses. Tinospora cordifolia (Guduchi) has many claimed benefits in animal studies but no proven clinical benefits in humans and has been linked to rare cases of liver injury.

If you decide to take Livital, be consistent with the dosage (usually one tablet twice a day) and monitor your health. Expect gentle digestive improvements in the first few weeks, followed by gradual normalisation of liver enzyme markers over the 90‑day course.

Consult your healthcare provider before starting, especially if you have existing liver or kidney conditions, and discontinue use if you experience jaundice, severe fatigue or other concerning symptoms.

Reference

1. Zandu Livital Liver Detox Tablets – Buy Clinically Proven Liver Detox Tablets Online - Zandu Care

https://zanducare.com/products/livital-liver-care-tablet

2. Safety and Effectiveness of Liv.52 DS in Patients With Varied Hepatic Disorders: An Open-Label, Multi-centre, Phase IV Study - PMC

https://pmc.ncbi.nlm.nih.gov/articles/PMC11112526/

Tinospora - LiverTox - NCBI Bookshelf

https://www.ncbi.nlm.nih.gov/books/NBK608429/

The use of Andrographis paniculata and its effects on liver biochemistry of patients with gastrointestinal problems in Thailand during the COVID-19 pandemic: a cross sectional study - PMC

https://pmc.ncbi.nlm.nih.gov/articles/PMC9617865/

Evaluation of the Effect of Cichorium intybus L. on the Liver Enzymes in Burn Patients: A Randomized Double-Blind Clinical Trial - PMC

https://pmc.ncbi.nlm.nih.gov/articles/PMC10796187/

Livital is marketed as a liver‑detox and revitalisation supplement. It combines several Ayurvedic herbs, including Kalmegh (Andrographis paniculata), Guduchi (Tinospora cordifolia), Bhringaraj (Eclipta alba), Punarnava (Boerhavia diffusa), Kasani (Cichorium intybus) and other botanicals such as tamalaki, katuka, vidanga and rohitaka.

According to the product information from Zandu Care, the tablets are intended to support liver and kidney health, improve metabolism and digestion and provide a detox effect when taken twice daily. Visible results are advertised in about two months.

Scientific Evidence on Polyherbal Liver Formulations

Study Details	Findings
Type of Study	Phase-IV, open-label clinical trial
Formula Tested	Liv.52 DS (related polyherbal formula, not Livital)
Sample Size	962 patients with mild-to-moderate liver disorders
Dosage	Two tablets, twice daily, for 12 weeks (≈90 days)
Outcome Measures	Improvements in liver enzyme and biomarker levels
Results	- 75% showed improved AST (aspartate aminotransferase) - 81% improved ALT (alanine aminotransferase) - 70% improved serum bilirubin - 79% improved ALP (alkaline phosphatase)
Statistical Significance	All improvements were significant (P < 0.0001)

Note: This study tested Liv.52 DS, not Livital. However, it indicates that polyherbal liver formulations may improve liver enzyme profiles over a 90-day period.

Below is a week‑by‑week guide synthesising evidence from this research, clinical trials on individual herbs and the product’s claims.

It is intended to provide a general idea of how your body might respond to Livital. Remember that individual responses vary, and you should consult a healthcare professional before starting any supplement.

Weeks 1–2: Gentle Detox and Digestive Support

Improved appetite and digestion: Punarnava and Bhringaraj are traditionally used to support digestion and reduce bloating. Bhringaraj contains phytochemicals that show hepatoprotective effects in animal studies, but human evidence is limited.

Subtle energy lift: As the herbs start supporting digestion, some users report feeling slightly lighter after meals. Guduchi is thought to help modulate immunity and metabolism, but LiverTox notes that none of its claimed benefits have been proven in human studies.

No major liver enzyme changes yet: In the Liv.52 DS study, most biochemical improvements were observed after several weeks of continuous use.

Weeks 3-4: Metabolic and Appetite Benefits

Better metabolism and less bloating: Kalmegh (Andrographis paniculata) contains andrographolide, which has anti‑inflammatory and antioxidant properties.

However, a Thai cross‑sectional study found that people taking Andrographis for gastrointestinal problems had slightly higher ALT and AST levels compared with non‑users. This suggests that high doses may strain the liver, so staying within recommended dosages is essential.

Support for kidney function: Punarnava and Kalmegh are considered diuretics and may help flush excess water from the body. Evidence is anecdotal, mainly or derived from animal studies.

Mild improvements in fatigue: Participants in the Liv.52 DS trial reported reductions in fatigue and anorexia symptoms by week 12, suggesting that energy levels may start improving by the end of this phase.

Weeks 5–6: Visible Changes in Liver Function Markers

Liver enzyme improvements begin: In the Liv.52 DS study, improvements in ALT, AST, bilirubin and ALP became significant around this time.

A separate double‑blind trial on burn patients found that chicory seed syrup (Cichorium intybus) decreased liver enzyme levels over 15 days. However, the difference from silymarin (milk thistle) was not significant.

Better digestion and appetite: Zandu notes that Livital improves appetite and digestion. Anecdotal reports often mention fewer episodes of nausea and a more regular appetite during this period.

Stay mindful of dosage: Andrographis consumption is associated with an increased risk of ALT elevation (adjusted odds ratio 1.62) so avoid exceeding recommended doses and consult a doctor if you have underlying liver issues.

Weeks 7–8: Metabolic Balance and Energy Gains

Enhanced metabolism and weight management: As the liver becomes more efficient at processing fats and toxins, some users may notice gradual weight stabilisation. Chicory (Kasani) contains inulin, a prebiotic fibre that can support gut microbiota and may improve blood sugar and cholesterol profiles.

Reduced abdominal discomfort: The diuretic and detoxifying herbs may help reduce water retention and discomfort around the abdomen. Again, data from human studies are limited; most evidence comes from preclinical research.

Improved mood and daily vitality: With digestion and liver function improving, you might experience better sleep and morning energy. However, Guduchi’s benefits on immune function remain unproven in humans.

Weeks 9–10: Liver Health and Wellbeing

Noticeable improvement in liver enzymes: Based on the Liv.52 DS trial, by around week 9, many participants had normalised ALT and AST levels. Serum bilirubin and ALP levels also improved in ~70–79 % of participants.

Better skin and hair: Bhringaraj and tamalaki are traditionally used for hair and skin health. While there is limited clinical research, users often report a healthier complexion as toxins are cleared more efficiently.

Caution with Guduchi: LiverTox reports more than 50 cases of acute liver injury linked to Tinospora cordifolia; the cases range from mild enzyme elevations to severe hepatitis. If you notice jaundice (yellowing of skin or eyes) or dark urine, stop the supplement and seek medical advice.

Weeks 11–12: Peak Benefits and Overall Wellness

Highest improvement in quality of life: The Liv.52 DS study measured quality‑of‑life scores and found significant improvements across all domains at 12 weeks. Fatigue, anorexia, and jaundice symptoms decreased markedly.

Stable digestion and metabolism: By this stage, your digestive system may feel more regular, and energy levels more consistent. Chicory’s prebiotic fibre continues to support gut health.

Monitoring and maintenance: Continue regular liver function tests if you have pre‑existing liver conditions. Stop the supplement if any unusual symptoms occur.

Key Signs That Livital May be Working

Indicator	Evidence/notes
Reduced fatigue and improved appetite	In the Liv.52 DS study, almost half of patients experienced relief from fatigue and appetite loss by week 12.
Improved liver enzymes	75 % of patients showed improved AST, 81 % improved ALT, 70 % reduced bilirubin and 79 % improved ALP by week 12.
Better digestion and metabolism	Product information notes improved digestion and appetite; chicory seed trials showed decreased liver enzyme levels over 15 days.
Stable weight and reduced bloating	Punarnava and Kalmegh have diuretic and digestive properties; anecdotal reports suggest less water retention and better metabolism, though clinical evidence is limited.
No significant side effects	The Liv.52 DS trial reported few adverse events (2.6 % abdominal pain and 1.7 % headache) and no serious safety signals.

The Outcome

Livital is a polyherbal supplement designed to support liver health, digestion and metabolism. The strongest evidence for similar formulas comes from a 12‑week open‑label study of Liv.52 DS, where around 75–81 % of participants experienced improvements in liver enzyme levels and clinical symptoms.

Individual herbs such as chicory show promise in reducing liver enzymes, while others like Andrographis may elevate ALT if taken at high doses. Tinospora cordifolia (Guduchi) has many claimed benefits in animal studies but no proven clinical benefits in humans and has been linked to rare cases of liver injury.

If you decide to take Livital, be consistent with the dosage (usually one tablet twice a day) and monitor your health. Expect gentle digestive improvements in the first few weeks, followed by gradual normalisation of liver enzyme markers over the 90‑day course.

Consult your healthcare provider before starting, especially if you have existing liver or kidney conditions, and discontinue use if you experience jaundice, severe fatigue or other concerning symptoms.

Reference

1. Zandu Livital Liver Detox Tablets – Buy Clinically Proven Liver Detox Tablets Online - Zandu Care

https://zanducare.com/products/livital-liver-care-tablet

2. Safety and Effectiveness of Liv.52 DS in Patients With Varied Hepatic Disorders: An Open-Label, Multi-centre, Phase IV Study - PMC

https://pmc.ncbi.nlm.nih.gov/articles/PMC11112526/

Tinospora - LiverTox - NCBI Bookshelf

https://www.ncbi.nlm.nih.gov/books/NBK608429/

The use of Andrographis paniculata and its effects on liver biochemistry of patients with gastrointestinal problems in Thailand during the COVID-19 pandemic: a cross sectional study - PMC

https://pmc.ncbi.nlm.nih.gov/articles/PMC9617865/

Evaluation of the Effect of Cichorium intybus L. on the Liver Enzymes in Burn Patients: A Randomized Double-Blind Clinical Trial - PMC

https://pmc.ncbi.nlm.nih.gov/articles/PMC10796187/

Written by

Zanducare

India’s trusted name in Ayurvedic wellness, offering time-tested solutions for today’s health and lifestyle needs. With formulations rooted in classical Ayurvedic texts and crafted using pure natural ingredients, we bring holistic care into your everyday routine.

Research by

Ayurvedic Consultant

Reviewed by certified BAMS doctors and Ayurvedic experts who combine classical Ayurvedic knowledge with modern clinical insights. We focus on personalised, root-cause-based recommendations for natural healing and holistic wellbeing.